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Onl J Bioinform©


Established 1995

ISSN  1443-2250

 

Volume 26 (2) : 77-84, 2025 

Effects of intron-2 RNA on Trypanosoma congolense P74 proteins.

 

Waren N. Baticados, Noboru Inoue, Chihiro Sugimoto, Hideyuki Nagasawa, Abigail M. Baticados.

 

College of Veterinary Medicine,University, Philippines, Obihiro University of Agriculture and Veterinary Medicine, Obihiro,

School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

 

ABSTRACT

 

Baticados WN, Inoue N, Sugimoto C), Nagasawa H, Baticados AM, Effects of intron-2 RNA on Trypanosoma congolense P74 proteins Onl J Bioinform., 26 (2) 77-84, 2025. Trypanosoma congolense RNA interference cell lines were obtained and functional analysis of Trypanosoma congolense P74 gene was performed using double-stranded RNA interference. The present study strongly indicates and further verified the data of the previous research that, P74 gene is stage-specific and the expression is developmentally up-regulated in Trypanosoma congolense bloodstream forms. The inability to determine the function due to the stage-specific expression of the gene still contributed to the understanding of the nature of the gene and double-stranded RNA interference in trypanosomes. The study further stresses that T. congolense is still amenable to double-stranded RNA interference and is a suitable for stage-specific gene expression.

 

Key words: Double-stranded RNA, Trypanosoma congolense,  proteins.

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