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OJBTM
Online Journal of Bioinformatics©
Established 1995
ISSN 1443-2250
Volume 22 (3): 230-257, 2021.
MicroRNAs in brain and genes associated with amyotrophic
lateral sclerosis.
Santosh P. Shinde, Neelima
Arora and Utpal Bhadra.
Functional
Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology,
Hyderabad-500007, India
Shinde SP, Arora N, Bhadra U., MicroRNAs in
brain and genes associated with amyotrophic lateral sclerosis, Onl J Bioinform., 22 (3): 230-257, 2021. Amyotrophic Lateral Sclerosis
(ALS) is a rare neurological disease affecting mainly motor neurons which can
lead to paralysis and death in extreme cases. We predicted target sites for microRNAs
in brain and CNS for 35 ALS associated genes. MicroRNA target sites were
classified by position and location for gene silencing verificed
by TargetScan and PicTar for sites in 3´ UTR. Target
sites (1456) for mRNA’s repression of gene expression were identified with miRanda algorithms. Most sites were
found in 5´ UTR and CDS region with 11 common to all (3) algorithms.
Key-words: MicroRNA,
CNS, genes, Sclerosis.
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