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OJBTM
Online Journal of Bioinformatics©
Established 1995
ISSN 1443-2250
Volume 23
(3):276-286, 2022.
In silico crystal
structure of UDP-glucose 4-epimerases from Catharanthus roseus.
Ramachandran M and Arunkumar DE.
Bioinformatics Centre, Central Agricultural Research
Institute, Port Blair, Andaman and Nicobar Islands, India.
ABSTRACT
Ramachandran M, Arunkumar DE., In silico crystal
structure of UDP-glucose 4-epimerases from Catharanthus
roseus, Onl J Bioinform., 23 (3):276-286, 2022. Glucose
4-Epimerase catalyses conversion of UDP-Glucose to
UDP-Galactose during glucose metabolism. The
reversible interconversion of UDP-D-glucose and UDP-D-galactose is catalyzed by
UDP-glucose 4-epimerase. D-galactose is widely distributed in combined form in
plants, animals and microorganisms as a constituent of oligo- and polysaccharides;
it also occurs in galactolipids and as its glucoside
in lactose and melibiose. We describe 3D crystal
structure of UDP-glucose 4-epimerase enzymes (EC 5.1.3.2) from Catharanthus roseus by
homologous structures against protein dabases
validated by PROCHECK and WHAT-IF. Hydropathicity was
calculated for binding in the validated model with 89% residues lie in most favored
region. We predicted 3 binding sites could be targets for inhibition.
Keywords: UDP – Glucose
4-Epimerase Enzyme, Model building, Validation , Hydropathicity, Drug target, Model validations.