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OJBTM
Online Journal of Bioinformatics ©
Volume 12(1):46-56,
2011.
In silico epitope rabies virus vaccine.
Tomar N Ra *, Marla S S a, Chandra Rb, Kumar Rc and Kumar Aa
aDepartment of Molecular Biology and Genetic Engineering, G.B.Pant university of Agriculture and Technology,
Pantanagar-263145,bDepartment of Veterinary Microbiology, G. B. Pant
university of Agriculture and Technology, Pantanagar-263145,cAnimal
Biotechnology section, Central Sheep and Wool Research Institute,
Avikanagar-304501, India
ABSTRACT
Tomar
NR, Marla SS, Chandra R, Kumar R, Kumar A., In silico epitope rabies virus
vaccine, Online J Bioinform.atics,
12(1):46-56,
2011. An epitope from
position 228-236 (T-228) was identified as a novel T cell epitope revealing
good MHC class I binding, processing and conservation in known rabies viruses.
The findings suggest that it may be possible to generate a synthetic peptide
vaccine against rabies but further research on G protein is required, including
a search for additional linear epitopes.
Key words: Epitope vaccine, T
cell epitopes, in-silico, rabies.
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