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Online Journal of Bioinformatics
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Established 1995

ISSN  1443-2250


Volume 19(2):208-213, 2018.


 

A  theoretical  approach  to  test  possible interaction  between  DNA  and  in silico platelet P2Y1 receptor.

 

Arnab Mukherjee.

 

Indian Institute of Technology Madras, India.

 

ABSTRACT

 

Mukherjee A., A  theoretical  approach  to  test  possible interaction  between  DNA  and  in silico platelet  P2Y1 receptor, Onl J Bioinform., 19(2):208-213, 2018. Purinergic receptors are proteins that respond to sensitization by  purine nucleotides to induce signal transduction pathways. The receptors are classified as ligand-gated ion channels (P2X type) and G-Protein Coupled Receptors (P2Y type). This work focuses on a purino receptor that is expressed greatly on the platelet surface as a high affinity ADP receptor to  induce platelet  aggregation. The receptor was analyzed in silico to determine if the P2Y1 receptor  (which evinces a remarkable affinity for ADP) would respond to DNA as well. Although  the  receptor  does not strictly fall into any known family of proteins complexing with DNA theoretical approaches showed that  the  receptor may be a suitable candidate for protein-DNA interaction.

 

KEYWORDS : platelets, purinergic receptors, P2Y1, DNA binding proteins, ADP, docking.


 

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