MAIN


©1996-2019 All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


OJBTM

Online Journal of Bioinformatics ©

Volume 13(3):375-381, 2012.


A Parkinson’s disease mitochondrial dysfunction pathway with gene hubs.

 

Indumathi  Kamatchi Balakrishnan MSc Mphil, Saranya Rangasamy MSc, Mphil, Jeyakumar Natarajan  PhD.

 

Department of Bioinformatics, Bharathiar University, Coimbatore, Tamilnadu, India.

 

ABSTRACT

 

Balakrishnan ik, Rangasamy s, Natarajan j., A Parkinson’s disease mitochondrial dysfunction pathway with gene hubs, Online J Bioinform., 13(3):375-381, 2012.  Mitochondrial dysfunction in Parkinsons disease leads to increased production of reactive oxygen species detrimental to neurons.  A mitochondrial dysfunction pathway map was constructed from the literature and KEGG database. The resulting network was topologically analyzed for target drug gene hubs.  Results suggest that OXIDATIVE STRESS (most significant), DJ-1, ALPHA SYNUCLEIN AGGREGATION, PI3 and KINASE/AKT SIGNALLING hubs could have potential therapeutic use.

 

KEY-WORDS: Parkinson’s disease, Oxidative stress, Mitochondrial dysfunction, Topological analysis


MAIN

FULL-TEXT(SUBSCRIPTION OR PURCHASE TITLE $25USD)