©1996-2019. All
Rights Reserved. Online Journal of Bioinformatics . You
may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties.
Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJB publications. This
article may be copied once but may not be, reproduced or re-transmitted
without the express permission of the editors. This
journal satisfies the refereeing requirements (DEST) for the Higher Education
Research Data Collection (Australia). Linking: To link to this
page or any pages linking to this page you must link directly to this page only
here rather than put up your own page.
OJBTM
Online Journal of Bioinformatics ©
Volume 16 (2): 254-262,
2015.
Review:
Genome-wide copy number variation from next generation sequencing data
Styliani
Loukatou1, Panagiotis Chatzinikolaou 1, 2 , Dimitrios Vlachakis1,3,4
and Sophia Kossida1,*
1Computational
Biology & Medicine Group, Biomedical Research Foundation, Academy of
Athens, 2,3Computer Engineering and Informatics Department,
University of Patras, 4Bionetwork ltd., Chalandri, Athens, Greece
ABSTRACT
Loukatou
S, Chatzinikolaou P, Vlachakis
D, Kossida S., Genome-wide copy number variation from
next generation sequencing data, Onl J Bioinform., 16 (2): 254-262,
2015. Next generation sequencing (NGS) is a low cost,
high-throughput genome sequencing method evolved from DNA sequencing and
converted to a parallel method outputting millions of sequences simultaneously
enabling a view of the entire
transcriptome. Copy number variations (CNVs) are DNA alterations in the
genome with an abnormal or normal variation in the number of copies of one or
more segments of DNA and describe large regions of our genome deleted or
duplicated on certain chromosomes.
Keywords: Next generation sequencing; Copy number
variation;
Structural Variation; genome;
FULL-TEXT (SUBSCRIBERS
OR PURCHASE TITLE $25USD)