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OJBTM
Online Journal of Bioinformatics©
Volume 21(2): 114-120,
2020.
Computational function annotation of hypothetical proteins in Listeria monocytogenes EGD-e.
Mital Naghera, John J George and
Trupti Kholia.
Department
of Bioinformatics, Christ College, Vidya Niketan, Rajkot – 360005, Gujarat, INDIA
ABSTRACT
Naghera M, George JJ, Kholia
T., Computational function annotation of hypothetical proteins in Listeria monocytogenes EGD-e, Onl J Bioinform., 21(2): 114-120, 2020. A
functional annotation of hypothetical proteins in Listeria monocytogenes EGD-e, is described. 436 hypothetical proteins were retrieved
from NCBI RefSeq. 432 proteins were then assigned by sequence
similarity PSI-BLAST; domain by InterProScan, Pfam, CDD, COGniter; secondary
fold by PHYRE; 3D homology model search using Metaserver
and biological function by PFP, ProtFun and TMHMM.
Using these tools, we have annotated most of the hypothetical proteins with
precision. We describe functional role of uncharacterized proteins involved in
metabolism, pathogenesis and other biological processes of L. monocytogenes EGD-e for identification of drug
targets.
Keywords: Listeria monocytogenes EGD-e, hypothetical proteins, function
annotation, listeriosis.
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