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OJBTM
Online Journal of
Bioinformatics©
Volume 21(2):
183-189, 2020.
Glycan
binding protein genes in streptococcus mutans as potential pathogens aligned to lectin
database
Saulo Alves Aflitos MSc1,2. Benildo
Sousa Cavada PhD1, Luzimar Gonzaga Fernandez PhD2, Frederico
Bruno Moreno PhD1,
Lucas de Lima Nogueira PhD1, Rafael
da Conceição Simões BSc1,2
1Laboratório de Moléculas Biologicamente
Ativas, BIOMOL-LAB, Fortaleza, Ceará, 2Laboratório de Estudos em
Meio Ambiente, LEMA, Salvador, Bahia, Brazil.
ABSTRACT
Aflitos
SA, Cavada BS, Fernandez LG, Moreno FB, Nogueira LL, Simões RC., Glycan
binding protein genes in streptococcus mutans as
potential pathogens aligned to lectin database, Onl J
Bioinform., 21(2): 183-189, 2020. Streptococcus mutans
is the etiologic agent of human caries being the major responsible for tooth
decay by its acid production, a byproduct from sugar’s degradation. This microorganism
uses Glycan Binding Proteins (GBPs – specifically sucrose-polymer-binding
proteins) to connect either to the Acquired
Enamel Pellicle (EAP) glycans created by the host’s
saliva, glycans from other bacteria’s membrane glucoproteins or glycans produced
by itself as mucilage for adhesion. Four GBPs are known for S. mutans virulence.
We describe GBPs sequences between unknown function proteins sequences from the
S. mutans
genome using a Lectin (GBP higher class) specific database. We found Genbank accession codes: NP_720544 and NP_722430 with high
sequence similarity to GBPs but not able to be extracted by automatic
annotation. These sequences should be further analyzed by biochemical and molecular
biology assays to confirm its expression and in vivo/in vitro functions.
Key words: Caries; Lectin; GBP; streptococcus mutans.
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