©1996-2019.
All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in
any form except for your own personal use. All other usage or distribution is
illegal under international copyright treaties. Permission to
use any of these pages in any other way besides the before mentioned must be
gained in writing from the publisher. This article is exclusively
copyrighted in its entirety to OJB publications. This article may be copied
once but may not be, reproduced or re-transmitted without the express
permission of the editors. This journal
satisfies the refereeing requirements (DEST) for the Higher Education Research
Data Collection (Australia). Linking:To
link to this page or any pages linking to this page you must link directly to
this page only here rather than put up your own page.
OJBTM
Online Journal of Bioinformatics ©
In Silico
drug targets for infectious endocarditis.
Priyadarshini V, Pradhan D, Munikumar M, Swargam S, Umamaheswari A, Rajasekhar D., In
Silico drug targets for infectious endocarditis, Online J Bioinform 14 (1): 32-50, 2013. Availability of
pathogens and the human genome sequence have facilitated identification of
common drug targets against infective endocarditis (IE). By implementing comparative
and subtractive genomics with metabolic pathway analysis, 18 common putative
drug targets were identified for 8 major pathogens of IE. MurB
was the only target found to use the peptidoglycan biosynthesis pathway unique
to bacteria. MurB target was therefore chosen to be
modeled (Modeller9v8). From the predicted model, allosteric site residues were located and validated through CASTp analysis. The In
Silico drug targets reported here could be used to design drug molecules
against infective endocarditis.
Keywords: Infective
endocarditis, MurB, Peptidoglycan biosynthesis,
Molecular modeling, Modeller.
FULL-TEXT (SUBSCRIBE OR PURCHASE
TITLE $25USD)