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OJB©
Online Journal of Bioinformatics©
Volume 5:132-145,
2004.
Prediction of transcriptional regulation by Dlx
and Msx homeodomain proteins.
Swarnalatha M, Jutur PP, Amouda
V, Mathur PP, Reddy AR
Bioinformatics
Centre, Department of Biochemistry and Molecular Biology, School of Life
Sciences Pondicherry University, Pondicherry - 605 014, India
ABSTRACT
Swarnalatha M, Jutur PP, Amouda V, Mathur PP, Reddy AR., Prediction of transcriptional
regulation by Dlx and Msx
homeodomain proteins, Onl J Bioinform., 5:132-145,
2004 Homeodomain
proteins are transcription factors that play a crucial role in early
development in eukaryotes and regulate mechanisms involved in switching off/on
specific subset of target genes. The Dlx & Msx homeoproteins are recruited
to the transcriptional control regions of specific target genes via selective
DNA-protein and/or protein-protein interactions and affect the activation or
repression of their respective target genes. The regulation of genes during
development, leading to the interactions between homeoproteins
and other transcription factors probably enhances additional level of
specificity. In this paper, we have studied the role of Dlx and Msx homeoproteins
in transcriptional regulation under these interactions using in silico methods, which would expand
the scope of experimental data to construct novel models for transcriptional
regulation.
KEYWORDS: Dlx-Msx heterodimerization, DNA-protein interaction,
helix-turn-helix, homeodomains, protein- protein interaction