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Journal of Bioinformatics©
Established 1995
ISSN 1443-2250
Volume 20(1):23-31,
2019.
Prediction patterns for initiation region of a- helix of proteins.
Baby Joseph1
and Vrundha M. Nair2
1Department(s)
of Biotechnology, 2Bioinformatics, Malankara Catholic College, Mariagiri, Kaliakkavilai - 629153,
Kanyakumari District, TamilNadu, India.
ABSTRACT
Joseph
B, Nair VM., Prediction patterns for initiation region of a- helix of proteins, Onl J Bioinform., 20(1):23-31,
2019. The
role of secondary and tertiary structure in protein folding remains unknown. Experiments
show that not all the proteins fold spontaneously in the cell. Molecular
chaperon proteins assist target proteins to initiate folding paths. Elucidation
of protein folding may assist treatment of Alzheimer’s, Huntington’s, Parkinson's, CJD, Mad Cow (BSE), and cancer. Prediction
of conserved patterns of secondary structural elements could increase accuracy
of secondary structure prediction and protein folding. We describe conserved
patterns in the initiation region of the alpha helix. The 3D structural details
of PDB flat files and PERL were used to identify frequency of triplet
occurrence in upstream and downstream initiation site of alpha helix. Three
high propensity conserved patterns were identified in the initiation region of
the alpha helix.
Keywords: alpha helix, protein folding, initiation site, PERL, PDB.
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