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OJBTM
Online Journal of
Bioinformatics ©
Volume 12(1):66-73, 2011
Partial
sequence clone of canine mammary tumor metalloproteinase MMP11 catalytic domain
B. V. Sunil
Kumar (M.V.Sc), Meena Kataria (M.Sc,Ph.D),
G.V.P.P.S. Ravi Kumar*(M.V.Sc,Ph.D), K. Aswani Kumar (M.V.Sc)
and A.P. Vishwanatha Reddy
Enzymology lab., Division of
Biochemistry, Indian Veterinary Research Institute, Izatnagar,
Bareilly-243122 (U.P.), India.
ABSTRACT
Sunil Kumar BV, Kataria M, Kumar R, Kumar KA, Vishwanatha
Reddy AP, Partial sequence clone of canine mammary tumor metalloproteinase
MMP11 catalytic domain, Onl J Bioinform., 12(1):66-73, 2011. Partial sequence of canine MMP11 catalytic domain was
cloned and sequenced (Acc o.HM037636). Nucleotide and translated protein
sequence was close to Equus caballus but clustered away from rodent and primate
groups. Synonymous substitution (dS) was higher than
non-synonymous substitution (dN)
suggesting that the catalytic domain MMP11 gene was not under positive
selection and that no advantageous mutations had had any significant role in
its evolutionary adaptation.
(Key words: Cloning,
Characterization, Matrix metalloproteinase 11, canine.
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