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Online Journal of Bioinformatics©
Established 1995
ISSN 1443-2250
Volume 20(2):62-75, 2019.
BTDB - Database on
Structural and Functional Information of Biotoxins.
Gowriishankar R and Sundara Baalaji N*
Structural Biology lab, Department of
Bioinformatics, School of life sciences, Bharathiar
University, Coimbatore – 641 046
ABSTRACT
Gowriishankar R, Baalaji SN., BTDB - Database on Structural and Functional
Information of Biotoxins, Onl
J Bioinform., 20(2):62-75,
2019. A biotoxic protein database could enable identification of
membrane proteins, ion channels on the surface of cancer cells. We describe primary
sequence databases for biotoxins from snake, spider
and scorpion. We intended to study the 3D structures of the toxin proteins by
homology modeling and validation of the structures through computational
methods that will ease wet lab works. Structural features of the models and the
putative functions are also predicted. For the easy access of the theoretically
modeled proteins and other related data, database named BTDB was created which
is user friendly and the information collected from this database will have the
implications on further insilico analysis on cancer
studies, designing drugs, studies on membrane proteins and identification of
ion channels.
This database can be accessed at the
URL: http://b-u.ac.in/btdb/
Keywords: Biotoxin,
Polypeptide, Homology
modeling, RMSD, Minimized energy, Database, HTML, MySQL